Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 18/20 | 0.35 |
| ▸ | CDK2 | P24941 | 18/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.35 |
| ▸ | AURKA | O14965 | 9/20 | 0.35 |
| ▸ | PLK1 | P53350 | 4/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCND3 | P30281 | 3/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473977 | 0.83 | CYP1A2 (0.33) | CCNA2CDK2CCNA1AURKACCNC | |
| SCHEMBL525783 | 0.82 | RAB9A (0.34) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL526227 | 0.78 | KDM4E (0.43) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL12473976 | 0.76 | TTK (0.42) | CCNA2CDK2CCNA1AURKATTK | |
| SCHEMBL1559147 | 0.73 | CCNA2 (0.36) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL525744 | 0.73 | CCNA2 (0.40) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9940540 | 0.72 | CCNA2 (0.57) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL525980 | 0.70 | RAB9A (0.39) | — | |
| SCHEMBL12466445 | 0.70 | NNMT (0.38) | CCNA2CDK2CCNA1AURKAPLK1 | |
| Phosphoric Acid SCHEMBL20600108 | 0.69 | CCNA2 (0.53) | CCNA2CDK2CCNA1AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | claimed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | claimed |
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |