Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261871 | 0.93 | ADORA2B (0.43) | PDE5AADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL5263935 | 0.85 | PDE5A (0.41) | PDE5A | |
| SCHEMBL5827731 | 0.82 | PDE5A (0.58) | PDE5AADORA1KDM4EALDH1A1GLA | |
| SCHEMBL5831080 | 0.81 | PDE5A (0.54) | PDE5A | |
| SCHEMBL6312729 | 0.81 | ADORA2A (0.54) | PDE5AADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL5830162 | 0.80 | PDE5A (0.54) | PDE5A | |
| SCHEMBL5830653 | 0.79 | PDE5A (0.51) | PDE5A | |
| SCHEMBL5262024 | 0.79 | PDE5A (0.42) | PDE5AADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL5830283 | 0.78 | PDE5A (0.56) | PDE5A | |
| SCHEMBL5827312 | 0.77 | PDE5A (0.57) | PDE5AADORA1KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307458-B1 | PYRROLOTRIAZOLOPYRIMIDINONE DERIVATIVES | ALMIRALL LAB (ES) | 2007-10-03 | — | — | EP | disclosed |