Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264419 | 0.76 | KDM4E (0.41) | KMT2AALDH1A1HTTPKMLMNA | |
| SCHEMBL5264746 | 0.76 | ALDH1A1 (0.39) | KMT2ARAB9AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6398309 | 0.76 | KMT2A (0.71) | KMT2ARAB9AMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL688068 | 0.75 | MAP2K2 (0.37) | RAB9AALDH1A1SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL3955084 | 0.75 | KMT2A (0.61) | KMT2ARAB9AMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL28405139 | 0.75 | KMT2A (0.57) | KMT2ARAB9AMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL5261896 | 0.75 | KEAP1 (0.40) | MAPT | |
| SCHEMBL4437870 | 0.74 | KMT2A (0.60) | KMT2ARAB9AMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL13844164 | 0.74 | KMT2A (0.60) | KMT2ARAB9AMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL346217 | 0.74 | KMT2A (0.64) | KMT2ARAB9AMITFALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |