Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14498820 | 0.89 | KCNH2 (0.48) | ATMKMT2AKCNH2 | |
| SCHEMBL14341457 | 0.87 | KCNH2 (0.40) | ATMKCNH2 | |
| SCHEMBL5264336 | 0.85 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL5261919 | 0.82 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL5263873 | 0.78 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL3251583 | 0.76 | SLC2A1 (0.39) | — | |
| SCHEMBL5259614 | 0.76 | KCNH2 (0.46) | KCNH2 | |
| SCHEMBL5263076 | 0.76 | KCNH2 (0.46) | KCNH2 | |
| SCHEMBL3252103 | 0.76 | KCNH2 (0.38) | ALDH1A1KCNH2 | |
| SCHEMBL3253063 | 0.76 | ALDH1A1 (0.37) | MEN1ALDH1A1HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399443-B1 | NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2007-12-12 | — | — | EP | claimed |