Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136052 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2A | |
| SCHEMBL3941089 | 0.82 | KDM4E (0.42) | SMN1; SMN2KDM4ETSHRHPGD | |
| SCHEMBL29951364 | 0.81 | LTA4H (0.43) | SMN1; SMN2GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL2559620 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1KMT2AGAA | |
| SCHEMBL12156678 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AHSD11B1 | |
| SCHEMBL21722045 | 0.77 | MAPT (0.55) | SMN1; SMN2KDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL7570551 | 0.75 | HRH3 (0.48) | SMN1; SMN2KDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL28164677 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL13629917 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL26833143 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2GNAI3GNAO1GNAI1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831229-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006071988-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORP. (US) | 2006-07-06 | — | — | WO | disclosed |