Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263075 | 1.00 | HRH1 (0.39) | HRH1HRH4ACHEHPGDL3MBTL1 | |
| SCHEMBL6181741 | 0.83 | HPGD (0.41) | HRH1HRH4HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL5400815 | 0.79 | HRH1 (0.35) | HRH1HRH4ACHEL3MBTL1ALDH1A1 | |
| SCHEMBL354099 | 0.77 | ACHE (0.53) | ACHEHPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL354098 | 0.77 | ACHE (0.53) | ACHEHPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL5970427 | 0.77 | ACHE (0.53) | ACHEHPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL29410363 | 0.77 | ACHE (0.53) | ACHEHPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL6947493 | 0.74 | MEN1 (0.39) | ACHEL3MBTL1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6947489 | 0.74 | MEN1 (0.39) | ACHEL3MBTL1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7230533 | 0.74 | HPGD (0.40) | HRH1HRH4ACHEHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836161-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006085149-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | WO | disclosed |