Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259875 | 0.91 | GPR119 (0.44) | GPR119MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5260678 | 0.90 | GPR119 (0.45) | GPR119L3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL5261167 | 0.90 | GPR119 (0.42) | GPR119MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5262751 | 0.88 | GPR119 (0.43) | GPR119MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL1673629 | 0.88 | GPR119 (0.59) | GPR119MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL1673801 | 0.79 | GPR119 (0.58) | GPR119MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL5263259 | 0.78 | GPR119 (0.61) | GPR119MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1673741 | 0.78 | GPR119 (0.55) | GPR119MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL1673971 | 0.78 | GPR119 (0.59) | GPR119MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL5259856 | 0.77 | GPR119 (0.61) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |