Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL908781 | 0.89 | KDM4E (0.47) | NAPRTDAOKDM4ESMN1; SMN2HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL17595211 | 0.79 | NAPRT (0.79) | NAPRTDAOKDM4EAURKAAURKB | |
| SCHEMBL29700994 | 0.73 | NOTUM (0.45) | DAOKDM4ESMN1; SMN2HSD17B10AURKA | |
| Trifluoroacetic Acid SCHEMBL12495925 | 0.72 | TSHR (0.47) | NAPRTKDM4ESMN1; SMN2GAALMNA | |
| Trifluoroacetic Acid SCHEMBL27924721 | 0.72 | NAPRT (0.38) | NAPRTDAOKDM4EGAAMAOB | |
| Trifluoroacetic Acid SCHEMBL5264519 | 0.72 | FKBP5 (0.64) | NAPRTDAOKDM4EGAA | |
| SCHEMBL24879524 | 0.69 | DAO (0.48) | NAPRTDAOKDM4EHSD17B10AURKA | |
| Trifluoroacetic Acid SCHEMBL3642493 | 0.69 | TSHR (0.44) | SMN1; SMN2GAALMNAMAOBMAOA | |
| SCHEMBL6984148 | 0.69 | DAO (0.52) | NAPRTDAOKDM4EAURKAAURKB | |
| Trifluoroacetic Acid SCHEMBL5801588 | 0.68 | GAA (0.43) | HSD17B10PPARGGAALMNAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869045-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107254-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |