Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263026 | 0.91 | AKT1 (0.43) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5261962 | 0.90 | AKT1 (0.43) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5260224 | 0.87 | AKT1 (0.41) | MAPK14AKT1AKT2 | |
| SCHEMBL5262863 | 0.85 | AKT1 (0.41) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5260597 | 0.84 | GPBAR1 (0.46) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5261629 | 0.84 | ALDH1A1 (0.46) | MAPK14AKT1AKT2PTGS2PTGS1 | |
| SCHEMBL5265348 | 0.84 | AKT1 (0.38) | MAPK14AKT1AKT2PTGS2PTGS1 | |
| SCHEMBL5260566 | 0.81 | MAPK14 (0.35) | MAPK14AKT1AKT2PTGS2PTGS1 | |
| SCHEMBL5266214 | 0.81 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5260859 | 0.81 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660500-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | S A L V A T LAB SA (ES) | 2007-12-12 | — | — | EP | disclosed |