Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261629 | 0.92 | ALDH1A1 (0.46) | AKT1AKT2MAPK14ALDH1A1HTT | |
| SCHEMBL5260224 | 0.88 | AKT1 (0.41) | AKT1AKT2MAPK14ALDH1A1HTT | |
| SCHEMBL5261621 | 0.88 | AKT1 (0.41) | AKT1AKT2MAPK14ALDH1A1HTT | |
| SCHEMBL5263328 | 0.86 | SYK (0.42) | AKT1AKT2MAPK14ALDH1A1ALOX15 | |
| SCHEMBL5263026 | 0.85 | AKT1 (0.43) | AKT1AKT2MAPK14ALDH1A1NPC1 | |
| SCHEMBL5262720 | 0.85 | TUBB4A (0.43) | AKT1AKT2ALDH1A1NPC1ADORA2A | |
| SCHEMBL5261962 | 0.84 | AKT1 (0.43) | AKT1AKT2MAPK14ALDH1A1PTGS2 | |
| SCHEMBL5263373 | 0.84 | MAPK14 (0.51) | AKT1AKT2MAPK14PTGS2PTGS1 | |
| SCHEMBL5263776 | 0.83 | HSP90AA1 (0.41) | AKT1AKT2MAPK14ALDH1A1ALOX15 | |
| SCHEMBL5262639 | 0.82 | AKT1 (0.36) | AKT1AKT2MAPK14ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660500-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | S A L V A T LAB SA (ES) | 2007-12-12 | — | — | EP | disclosed |