⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050336 | 0.88 | KDM4E (0.33) | — | |
| SCHEMBL1924707 | 0.82 | — | — | |
| SCHEMBL293923 | 0.78 | — | — | |
| SCHEMBL18787310 | 0.78 | — | — | |
| SCHEMBL294358 | 0.78 | — | — | |
| SCHEMBL8924497 | 0.76 | ALDH1A1 (0.41) | — | |
| SCHEMBL2256248 | 0.75 | PDE4A (0.32) | — | |
| SCHEMBL28617675 | 0.74 | — | — | |
| SCHEMBL3432982 | 0.74 | TDP1 (0.38) | — | |
| SCHEMBL1477284 | 0.74 | HRH3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868740-B2 | Pyrimidinone compounds which are HNE inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-16 | — | — | US | claimed |
| EP-3154977-A1 | NOVEL COMPOUNDS | Chiesi Farmaceutici S.p.A. (IT) | 2017-04-19 | — | — | EP | claimed |
| US-20170101413-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-04-13 | — | — | US | claimed |
| WO-2015188866-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-17 | — | — | WO | claimed |
| US-9868740-B2 | Pyrimidinone compounds which are HNE inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-16 | — | — | US | disclosed |
| EP-3154977-A1 | NOVEL COMPOUNDS | Chiesi Farmaceutici S.p.A. (IT) | 2017-04-19 | — | — | EP | disclosed |
| US-20170101413-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-04-13 | — | — | US | disclosed |
| WO-2015188866-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-17 | — | — | WO | disclosed |
| EP-1824817-A1 | ARYLSULFONYLNAPHTHALENE DERIVATIVES AS 5HT2A ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006059149-A1 | ARYLSULFONYLNAPHTHALENE DERIVATIVES AS 5HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-06-08 | — | — | WO | disclosed |