Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389163 | 0.89 | GPR119 (0.61) | GPR119 | |
| SCHEMBL4720771 | 0.84 | GPR119 (0.48) | GPR119NPC1RAB9AFLT3CDK2 | |
| SCHEMBL13685341 | 0.81 | GPR119 (0.53) | GPR119FLT3CDK2CDK6ERBB2 | |
| SCHEMBL1830976 | 0.79 | GPR119 (0.45) | GPR119FLT3CDK2CDK6EGFR | |
| SCHEMBL5188992 | 0.78 | GPR119 (0.45) | GPR119FLT3CDK2CDK6ERBB2 | |
| SCHEMBL1070555 | 0.78 | GPR119 (0.47) | GPR119FLT3CDK2CDK6EGFR | |
| SCHEMBL5046848 | 0.76 | GPR119 (0.44) | GPR119FLT3CDK2CDK6ERBB2 | |
| SCHEMBL3866032 | 0.74 | GPR119 (0.48) | GPR119FLT3CDK2CDK6ERBB2 | |
| SCHEMBL5048764 | 0.74 | GPR119 (0.49) | GPR119FLT3CDK2CDK6ERBB2 | |
| SCHEMBL5264283 | 0.73 | GPR119 (0.62) | GPR119FLT3CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-A2 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005121121-A2 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | WO | claimed |