Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.53 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388449 | 0.88 | GPR119 (0.70) | GPR119CYP2C9KCNH2 | |
| SCHEMBL391509 | 0.88 | GPR119 (0.54) | GPR119 | |
| SCHEMBL4719749 | 0.83 | GPR119 (0.45) | GPR119EGFRFLT3CDK2CDK6 | |
| SCHEMBL4723041 | 0.83 | GPR119 (0.55) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL5264014 | 0.81 | GPR119 (0.46) | GPR119EGFRFLT3CDK2CDK6 | |
| SCHEMBL5264283 | 0.80 | GPR119 (0.62) | GPR119FLT3CDK2CDK6CYP2C9 | |
| SCHEMBL5188992 | 0.80 | GPR119 (0.45) | GPR119EGFRFLT3CDK2CDK6 | |
| SCHEMBL386785 | 0.79 | GPR119 (0.80) | GPR119CYP2C9KCNH2 | |
| SCHEMBL1073405 | 0.78 | GPR119 (0.47) | GPR119EGFRFLT3CDK2CDK6 | |
| SCHEMBL3866032 | 0.77 | GPR119 (0.48) | GPR119EGFRFLT3CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758565-B2 | Method of identifying GLP-1 secretagogues | ARENA PHARM INC (US) | 2012-11-14 | — | — | EP | disclosed |
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |