Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262162 | 0.91 | GPR119 (0.61) | GPR119MAPTALDH1A1KDM4ECYP2C9 | |
| SCHEMBL5264529 | 0.89 | GPR119 (0.66) | GPR119MAPTALDH1A1ACACBLMNA | |
| SCHEMBL5260271 | 0.89 | GPR119 (0.58) | GPR119MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL1673588 | 0.88 | GPR119 (0.78) | GPR119MAPTALDH1A1KDM4EPOLB | |
| SCHEMBL5263835 | 0.88 | GPR119 (0.78) | GPR119MAPTALDH1A1ACACBLMNA | |
| SCHEMBL5263099 | 0.88 | GPR119 (0.65) | GPR119MAPTALDH1A1ACACBLMNA | |
| SCHEMBL5259999 | 0.87 | GPR119 (0.69) | GPR119MAPTALDH1A1ACACBLMNA | |
| SCHEMBL5262168 | 0.87 | GPR119 (0.64) | GPR119MAPTALDH1A1ACACBLMNA | |
| SCHEMBL5261101 | 0.87 | GPR119 (0.68) | GPR119MAPTALDH1A1ACACBLMNA | |
| SCHEMBL5263259 | 0.87 | GPR119 (0.61) | GPR119MAPTALDH1A1ACACBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |