Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3438911 | 0.69 | ALDH1A1 (0.39) | TSHRKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL23199903 | 0.68 | NPC1 (0.42) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL28690804 | 0.68 | ERAP1 (0.44) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL28690803 | 0.68 | ERAP1 (0.44) | TSHRKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL3659620 | 0.68 | BCHE (0.40) | TSHRKDM4EALDH1A1BCHE | |
| SCHEMBL555308 | 0.67 | KDM4E (0.57) | TSHRKDM4EBCHE | |
| Bicarbonate SCHEMBL27892668 | 0.67 | TSHR (0.59) | TSHRKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22231450 | 0.67 | MMP12 (0.46) | SMN1; SMN2ANPEPERAP1ERAP2ACP3 | |
| SCHEMBL22231452 | 0.67 | MMP12 (0.46) | SMN1; SMN2ANPEPERAP1ERAP2ACP3 | |
| SCHEMBL22783583 | 0.67 | SMN1; SMN2 (0.43) | TSHRKDM4EKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |