Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.64 |
| ▸ | KDR | P35968 | 9/20 | 0.60 |
| ▸ | KIT | P10721 | 4/20 | 0.60 |
| ▸ | FLT3 | P36888 | 4/20 | 0.60 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877955 | 0.81 | RIPK1 (0.56) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL4662498 | 0.80 | KDR (0.60) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL13979911 | 0.79 | KDR (0.59) | RIPK1KDRKITFLT3CSF1R | |
| Hydrochloric Acid SCHEMBL4475918 | 0.79 | KDR (0.59) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL13632600 | 0.78 | RIPK1 (1.00) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL28078227 | 0.78 | CA12 (0.60) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL24710786 | 0.77 | FLT1 (0.71) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL4477408 | 0.76 | KDR (0.61) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL1924576 | 0.76 | CA12 (0.55) | RIPK1KDRKITFLT3CSF1R | |
| SCHEMBL13712893 | 0.76 | KDR (0.53) | RIPK1KDRKITFLT3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841762-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | Aventis Pharma S.A. (FR) | 2007-10-10 | — | — | EP | claimed |
| WO-2006061493-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2006-06-15 | — | — | WO | claimed |