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SCHEMBL5264649

SCHEMBL5264649

Cc1ccc(C)c(N2CCN(C(=O)C3CN(S(=O)(=O)c4ccc(Cl)cc4)CC3c3ccccc3)CC2)c1

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 12/20 0.52
▸ AR P10275 5/20 0.49
▸ USP2 O75604 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.48
▸ LMNA P02545 1/20 0.48
▸ MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9926046 1.00 MC4R (0.52) MC4RARUSP2HTTNPSR1
SCHEMBL9926039 0.91 LMNA (0.52) MC4RARUSP2HTTNPSR1
SCHEMBL9926136 0.86 USP2 (0.57) ARUSP2HTTNPSR1LMNA
SCHEMBL14269767 0.86 USP2 (0.57) ARUSP2HTTNPSR1LMNA
SCHEMBL9926098 0.86 USP2 (0.57) ARUSP2HTTNPSR1LMNA
SCHEMBL9926101 0.85 SMN1; SMN2 (0.47) MC4RARUSP2LMNAMAPT
SCHEMBL4849442 0.85 LMNA (0.48) ARUSP2HTTLMNAMAPT
SCHEMBL4847578 0.85 LMNA (0.48) ARUSP2HTTLMNAMAPT
SCHEMBL9925998 0.85 AR (0.46) MC4RARUSP2MAPT
SCHEMBL5270813 0.85 AR (0.46) MC4RARUSP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1836180-A2 SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS sanofi-aventis (FR) 2007-09-26 — — EP disclosed
WO-2006072393-A2 SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS SANOFI-AVENTIS (DE) 2006-07-13 — — WO disclosed