Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.32 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263332 | 0.88 | AKT1 (0.38) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5261962 | 0.86 | AKT1 (0.43) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5261650 | 0.86 | ROCK2 (0.46) | AKT1AKT2PTGS1PTGS2MAPT | |
| SCHEMBL5263379 | 0.85 | AKT1 (0.39) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5267408 | 0.84 | AKT1 (0.38) | AKT1AKT2MAPK14MAPTSMN1; SMN2 | |
| SCHEMBL5262731 | 0.81 | AKT1 (0.47) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5260859 | 0.81 | MAPK14 (0.42) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5265447 | 0.80 | AKT1 (0.54) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5263183 | 0.80 | AKT1 (0.49) | AKT1AKT2PTGS1PTGS2MAPK14 | |
| SCHEMBL5264741 | 0.79 | AKT1 (0.39) | AKT1AKT2MAPK14MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660500-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | S A L V A T LAB SA (ES) | 2007-12-12 | — | — | EP | disclosed |