Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 9/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 9/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240048 | 1.00 | CDK5 (0.54) | CDK5CDK5R1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5238299 | 0.83 | CDK5 (0.53) | CDK5CDK5R1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL5237300 | 0.73 | CDK5 (0.67) | CDK5CDK5R1 | |
| SCHEMBL5238812 | 0.72 | CDK5 (1.00) | CDK5CDK5R1 | |
| SCHEMBL5323111 | 0.72 | CHRNB1 (0.43) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL13914679 | 0.67 | CHRNB2 (0.72) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL1793216 | 0.64 | CHRNB4 (0.61) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1793213 | 0.64 | CHRNB4 (0.61) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1797378 | 0.64 | CHRNB4 (0.61) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5238143 | 0.63 | CDK5 (0.55) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-B1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC (US) | 2007-02-28 | — | — | EP | disclosed |