Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.48 |
| ▸ | MMP13 | P45452 | 6/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP10 | P09238 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688025 | 0.91 | EGLN1 (0.44) | EGLN1MMP13MMP8KMT2AALDH1A1 | |
| SCHEMBL4935715 | 0.87 | ALDH1A1 (0.50) | EGLN1MMP13MMP8KMT2AALDH1A1 | |
| SCHEMBL4936417 | 0.83 | MMP13 (0.49) | EGLN1MMP13MMP8KMT2AKDM4E | |
| SCHEMBL4930446 | 0.78 | MMP13 (0.54) | MMP13MMP8MMP2MMP10 | |
| SCHEMBL4936609 | 0.78 | MMP13 (0.47) | EGLN1MMP13MMP8MMP2MMP10 | |
| SCHEMBL689082 | 0.78 | ALDH1A1 (0.49) | EGLN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4937662 | 0.78 | MMP13 (0.51) | MMP13MMP8MMP2MMP10 | |
| SCHEMBL4934644 | 0.78 | MMP13 (0.56) | MMP13MMP8POLBMMP2MMP10 | |
| SCHEMBL8186314 | 0.77 | EGLN1 (0.42) | EGLN1MMP13MMP8KMT2AALDH1A1 | |
| SCHEMBL4936900 | 0.77 | ALDH1A1 (0.48) | MMP13KMT2AALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |