Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 14/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412151 | 0.92 | MAP3K14 (0.47) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| Hydroxyamine SCHEMBL5265983 | 0.89 | MAP3K14 (0.50) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL415146 | 0.89 | MAP3K14 (0.50) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL412000 | 0.89 | MAP3K14 (0.50) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL412682 | 0.87 | MAP3K14 (0.46) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL411998 | 0.86 | MAP3K14 (0.47) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL413826 | 0.84 | AKT1 (0.46) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL409977 | 0.84 | MAP3K14 (0.45) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL413066 | 0.84 | MAP3K14 (0.45) | MAP3K14PIK3CDPIK3R1CDK4CDK2 | |
| SCHEMBL413617 | 0.83 | TGFBR1 (0.50) | MAP3K14PIK3CDPIK3R1CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |