Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.50 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409368 | 0.92 | TGFBR1 (0.42) | TGFBR1AKT1AKT2KDM4EALDH1A1 | |
| SCHEMBL409977 | 0.90 | MAP3K14 (0.45) | TGFBR1AKT1AKT2KDM4EHSD17B10 | |
| SCHEMBL407985 | 0.89 | TGFBR1 (0.46) | TGFBR1TP53MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL412682 | 0.89 | MAP3K14 (0.46) | TGFBR1MAP3K14PIK3CDPIK3R1IGF1R | |
| SCHEMBL27615221 | 0.88 | MAP3K14 (0.41) | TGFBR1AKT1AKT2KDM4EALDH1A1 | |
| SCHEMBL411998 | 0.87 | MAP3K14 (0.47) | TGFBR1AKT1AKT2MAP3K14PIK3CD | |
| SCHEMBL412151 | 0.87 | MAP3K14 (0.47) | TGFBR1AKT1AKT2MAP3K14TRIM33 | |
| SCHEMBL412286 | 0.86 | NPC1 (0.43) | TGFBR1KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL412220 | 0.85 | TGFBR1 (0.43) | TGFBR1KDM4ETP53MAP3K14PIK3CD | |
| SCHEMBL413826 | 0.84 | AKT1 (0.46) | TGFBR1AKT1AKT2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |