Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913811 | 0.87 | MAPK8 (0.42) | MAPK8MAPK14MAPK9MAPK10CCNE1 | |
| SCHEMBL5913834 | 0.87 | MAPK8 (0.42) | MAPK8MAPK14MAPK9MAPK10CCNE1 | |
| SCHEMBL5913945 | 0.86 | MCHR1 (0.52) | MAPK8MAPK14MCHR1ADRA2AHRH1 | |
| SCHEMBL5913954 | 0.86 | MCHR1 (0.52) | MAPK8MAPK14MCHR1ADRA2AHRH1 | |
| SCHEMBL5913964 | 0.86 | MAPK8 (0.44) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5914425 | 0.83 | IKBKB (0.47) | MAPK8MAPK14CDK2CYP2C9CCNA2 | |
| SCHEMBL5914134 | 0.81 | MAPK8 (0.44) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5914206 | 0.78 | MAPK8 (0.41) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5914214 | 0.78 | MAPK8 (0.41) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5914139 | 0.78 | MCHR1 (0.43) | CCNE1CDK2CCNE2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | claimed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | claimed |
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | claimed |
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | MAPK8 1760/4885MAPK14 2620/4885MAPK9 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.