Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 6/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913834 | 1.00 | MAPK8 (0.42) | MAPK8MAPK14MELKMAPK9MAPK10 | |
| SCHEMBL5266019 | 0.87 | MAPK8 (0.54) | MAPK8MAPK14MAPK9MAPK10CCNE1 | |
| SCHEMBL5913876 | 0.85 | TAAR1 (0.46) | MAPK14AURKA | |
| SCHEMBL5913896 | 0.85 | TAAR1 (0.46) | MAPK14AURKA | |
| SCHEMBL5913964 | 0.82 | MAPK8 (0.44) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5914206 | 0.81 | MAPK8 (0.41) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5914214 | 0.81 | MAPK8 (0.41) | MAPK8MAPK14MAPK9MAPK10CDK2 | |
| SCHEMBL5913954 | 0.80 | MCHR1 (0.52) | MAPK8MAPK14MCHR1ADRA2AAURKB | |
| SCHEMBL5913945 | 0.80 | MCHR1 (0.52) | MAPK8MAPK14MCHR1ADRA2AAURKB | |
| SCHEMBL5914425 | 0.79 | IKBKB (0.47) | MAPK8MAPK14CDK2CYP2C9CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | MAPK8 1760/4885MAPK14 2620/4885MELK 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.