Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.58 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.58 |
| ▸ | PRKCI | P41743 | 9/20 | 0.54 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.48 |
| ▸ | IKBKB | O14920 | 5/20 | 0.47 |
| ▸ | CHUK | O15111 | 5/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120405 | 0.81 | CCNK (0.62) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL20839795 | 0.71 | CCNK (0.65) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL1838406 | 0.70 | NUDT1 (0.67) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL730230 | 0.69 | CCNK (0.63) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL29635553 | 0.69 | PRKCI (0.64) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL1717710 | 0.68 | PRKCI (0.61) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL1718138 | 0.68 | NUDT1 (0.67) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL2240671 | 0.67 | AURKB (0.71) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL17673079 | 0.67 | IKBKB (0.61) | CCNKCDK12PRKCINUDT1IKBKB | |
| SCHEMBL2239087 | 0.67 | IKBKB (0.61) | CCNKCDK12PRKCINUDT1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846392-A2 | HETEROCYCLIC TRIAZINES AS HYPOXIC SELECTIVE PROTEIN KINASE INHIBITORS | Sentinel Oncology Limited (GB) | 2007-10-24 | — | — | EP | claimed |
| WO-2006131835-A2 | HETEROCYCLIC TRIAZINES AS HYPOXIC SELECTIVE PROTEIN KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2006-12-14 | — | — | WO | claimed |