Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5275008 | 0.92 | POLB (0.56) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5272559 | 0.91 | LMNA (0.51) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5269635 | 0.90 | ABCG2 (0.47) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5270805 | 0.89 | LMNA (0.48) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5273366 | 0.88 | ABCG2 (0.48) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5273841 | 0.87 | NPSR1 (0.52) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5273855 | 0.87 | ABCB1 (0.46) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5271151 | 0.86 | ABCG2 (0.48) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5270810 | 0.86 | ABCB1 (0.48) | POLBABCG2ABCB1PKMMAPT | |
| SCHEMBL5273285 | 0.86 | ALDH1A1 (0.57) | POLBABCG2ABCB1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868600-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE DEPENDENCY | Grünenthal GmbH (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006108565-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE DEPENDENCY | Grünenthal GmbH (DE) | 2006-10-19 | — | — | WO | disclosed |