Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 4/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5128215 | 0.99 | TOP2A (0.47) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| SCHEMBL5114390 | 0.92 | TOP2A (0.56) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| Hydrochloric Acid SCHEMBL5128015 | 0.91 | TOP2A (0.48) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| SCHEMBL5264250 | 0.87 | ADRA1B (0.48) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| Hydrochloric Acid SCHEMBL5116930 | 0.86 | ADRA1B (0.47) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| SCHEMBL5126942 | 0.85 | TOP2A (0.45) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| SCHEMBL5117968 | 0.85 | ADRA1B (0.48) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| SCHEMBL5117557 | 0.85 | ADRA1B (0.48) | TOP2AHDAC7HDAC9HDAC5ADRA1B | |
| SCHEMBL5266344 | 0.84 | ADRA1B (0.44) | TOP2AHDAC7HDAC9HDAC5HDAC3 | |
| SCHEMBL5317735 | 0.84 | ADRA1B (0.46) | TOP2AHDAC7HDAC9HDAC5HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791840-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2007-06-06 | — | — | EP | claimed |
| WO-2006029980-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-23 | — | — | WO | claimed |
| EP-1791840-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029980-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-23 | — | — | WO | disclosed |