Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528027 | 0.81 | KDM4E (0.50) | KDM4EPIM1PIM2KMT2AGAA | |
| SCHEMBL526632 | 0.77 | KDM4E (0.44) | KDM4EPIM1PIM2KMT2AGAA | |
| SCHEMBL527171 | 0.77 | KDM4E (0.47) | KDM4EPIM1PIM2KMT2AGAA | |
| SCHEMBL12768367 | 0.75 | MAPK8 (0.46) | KDM4EPIM1PIM2KMT2AGAA | |
| SCHEMBL2624169 | 0.74 | KMT2A (0.52) | KDM4EPDK2PDK1PDK3PDK4 | |
| SCHEMBL527746 | 0.73 | PSMD14 (0.46) | KDM4EPIM1PIM2KMT2AGAA | |
| SCHEMBL2688734 | 0.73 | PIM1 (0.66) | KDM4EPIM1PIM2GAAPKN1 | |
| SCHEMBL10136673 | 0.73 | PIM1 (0.63) | KDM4EPIM1PIM2GAAPKN1 | |
| SCHEMBL1527651 | 0.73 | PIM1 (0.50) | KDM4EPIM1PIM2KMT2AGAA | |
| SCHEMBL26406683 | 0.73 | CFTR (0.47) | KDM4EPIM1PIM2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | disclosed |
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | disclosed |
| US-8710044-B2 | Bicyclic azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-04-29 | — | — | US | disclosed |
| EP-2598492-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
| WO-2012013282-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
| WO-2012013282-A1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137677-A1 | Bicyclic Azaheterocyclic Carboxamides | CCNI, CCNA1, CCNA2 | KDM4E 426/4885PIM1 1671/4885PIM2 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.