Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 8/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.34 |
| ▸ | SYK | P43405 | 5/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042602 | 0.82 | GSK3A (0.38) | GSK3AGSK3BAURKAAURKBSYK | |
| SCHEMBL13221325 | 0.81 | GSK3B (0.54) | GSK3AGSK3BAURKAAURKBITK | |
| SCHEMBL13221349 | 0.79 | GSK3B (0.43) | GSK3AGSK3BAURKAAURKBSRC | |
| SCHEMBL13221315 | 0.77 | GSK3A (0.41) | GSK3AGSK3BAURKAAURKBSYK | |
| SCHEMBL3031628 | 0.76 | GSK3A (0.42) | GSK3AGSK3BAURKAAURKBITK | |
| SCHEMBL13221341 | 0.76 | ALDH1A1 (0.46) | GSK3AGSK3BAURKAAURKBSRC | |
| SCHEMBL5262600 | 0.75 | GSK3A (0.41) | GSK3AGSK3BAURKAAURKBITK | |
| SCHEMBL3037557 | 0.75 | GSK3A (0.39) | GSK3AGSK3BAURKAAURKBSYK | |
| SCHEMBL5262598 | 0.75 | NPC1 (0.41) | GSK3AGSK3BAURKAAURKBITK | |
| SCHEMBL3037823 | 0.75 | HTR6 (0.37) | GSK3AGSK3BAURKBSYKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812439-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044687-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-04-27 | — | — | WO | disclosed |