Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP10 | P09238 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186314 | 0.86 | EGLN1 (0.42) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL688951 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2AKDM4EPOLBMAPT | |
| SCHEMBL8198011 | 0.78 | HPGD (0.45) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL5260896 | 0.78 | EGLN1 (0.56) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL5265986 | 0.77 | EGLN1 (0.48) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL688025 | 0.76 | EGLN1 (0.44) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL13343656 | 0.74 | EGLN1 (0.39) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL8196873 | 0.74 | EGLN1 (0.39) | EGLN1ALDH1A1KMT2AKDM4EPOLB | |
| SCHEMBL8204571 | 0.72 | KMT2A (0.58) | ALDH1A1KMT2AKDM4EPOLBMAPT | |
| SCHEMBL13343699 | 0.72 | ALDH1A1 (0.44) | EGLN1ALDH1A1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |