Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272791 | 0.93 | AKR1C3 (0.52) | CCR2PTGS2HDAC1HDAC2HDAC8 | |
| SCHEMBL5267381 | 0.92 | CCR2 (0.54) | CCR2PTGS2ABCB11 | |
| SCHEMBL6648744 | 0.81 | PTGS2 (0.53) | CCR2PTGS2PTGDR2 | |
| SCHEMBL5267237 | 0.79 | AKR1C3 (0.73) | PTGS2AKR1C3AKR1C2PTGDR2ABCB11 | |
| Acetic Acid SCHEMBL3967081 | 0.75 | CCR2 (0.63) | CCR2PTGS2AKR1C3AKR1C2PLA2G2A | |
| SCHEMBL9958841 | 0.74 | HDAC1 (0.55) | CCR2PTGS2HDAC1HDAC2HDAC8 | |
| SCHEMBL5269846 | 0.73 | AKR1C3 (0.70) | PTGS2AKR1C3AKR1C2PTGDR2ABCB11 | |
| SCHEMBL6085520 | 0.73 | CCR2 (0.56) | CCR2PTGS2AKR1C3AKR1C2PLA2G2A | |
| SCHEMBL5266834 | 0.71 | AKR1C3 (0.73) | PTGS2AKR1C3AKR1C2PTGDR2ABCB11 | |
| SCHEMBL5266160 | 0.70 | AKR1C3 (0.72) | PTGS2AKR1C3AKR1C2PTGDR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225882-B1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | UNIV VANDERBILT (US) | 2007-10-17 | — | — | EP | claimed |
| EP-1225882-A4 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | UNIV VANDERBILT (US) | 2004-12-29 | — | — | EP | claimed |
| JP-2003508433-A | — | — | 2003-03-04 | — | — | JP | claimed |
| EP-1225882-A1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | Vanderbilt University (US) | 2002-07-31 | — | — | EP | claimed |
| US-6306890-B1 | COMPOUNDS FOR INHIBITING CYCLOOXYGENASE | VANDERBILT UNIVERSITY | 2001-10-23 | — | — | US | claimed |
| WO-2001015686-A1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | VANDERBILT UNIVERSITY (US) | 2001-03-08 | — | — | WO | claimed |
| EP-1225882-B1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | UNIV VANDERBILT (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1225882-A4 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | UNIV VANDERBILT (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1225882-A1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | Vanderbilt University (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6306890-B1 | COMPOUNDS FOR INHIBITING CYCLOOXYGENASE | VANDERBILT UNIVERSITY | 2001-10-23 | — | — | US | disclosed |
| WO-2001015686-A1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | VANDERBILT UNIVERSITY (US) | 2001-03-08 | — | — | WO | disclosed |