Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120022 | 0.78 | — | — | |
| SCHEMBL24351052 | 0.77 | NUDT1 (0.39) | NUDT1MAPK8SMN1; SMN2HPGDNQO1 | |
| SCHEMBL2221308 | 0.77 | KDM4E (0.40) | NUDT1MAPK8SMN1; SMN2HPGDNQO1 | |
| SCHEMBL3817284 | 0.77 | MAPK8 (0.41) | NUDT1MAPK8SMN1; SMN2HPGDNQO1 | |
| SCHEMBL11036646 | 0.75 | NUDT1 (0.65) | NUDT1SMN1; SMN2MAPTMAPK1NPC1 | |
| SCHEMBL12191906 | 0.72 | ALDH1A1 (0.36) | NUDT1MAPK8SMN1; SMN2HPGDNQO1 | |
| SCHEMBL2410520 | 0.72 | GAA (0.48) | NUDT1MAPK8SMN1; SMN2HPGDMAPT | |
| SCHEMBL24714984 | 0.72 | NUDT1 (0.43) | NUDT1MAPK8SMN1; SMN2HPGDNQO1 | |
| SCHEMBL16511927 | 0.71 | MAPT (0.41) | MAPK8NQO1BTKMAPTMAPK1 | |
| SCHEMBL15087992 | 0.71 | MAPK8 (0.49) | MAPK8SMN1; SMN2NQO1BTKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598481-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |