Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274888 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5268051 | 0.81 | MAPT (0.42) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5272473 | 0.81 | MAPT (0.46) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5340346 | 0.77 | MAPT (0.43) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5342565 | 0.77 | MAPT (0.45) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5336428 | 0.76 | MAPT (0.39) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5274523 | 0.76 | MAPT (0.42) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5266671 | 0.75 | POLB (0.41) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5271822 | 0.75 | MAPT (0.49) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL5270761 | 0.74 | PPARD (0.33) | KDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844013-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006077364-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |