Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MMP13 | P45452 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274230 | 0.91 | HPGD (0.49) | HPGDHDAC1KMT2AALDH1A1 | |
| SCHEMBL5270246 | 0.90 | NPC1 (0.57) | HPGDHTTSMN1; SMN2HDAC1ALDH1A1 | |
| SCHEMBL5266786 | 0.89 | MEN1 (0.54) | HPGDLMNASMN1; SMN2HDAC1KMT2A | |
| SCHEMBL5269714 | 0.88 | ROCK2 (0.54) | HPGDMMP13EPHX2HDAC1 | |
| SCHEMBL5270473 | 0.87 | MAPK14 (0.53) | HPGDMAPK14SMN1; SMN2PPARGPPARA | |
| SCHEMBL5320217 | 0.85 | MAPK14 (0.55) | HPGDMAPK14LMNAPPARGPPARA | |
| SCHEMBL5270730 | 0.85 | HPGD (0.69) | HPGDHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5271587 | 0.83 | HPGD (0.51) | HPGDHTTMMP13SMN1; SMN2HDAC1 | |
| SCHEMBL5271746 | 0.81 | ALDH1A1 (0.50) | HPGDHTTHDAC1KMT2AMMP2 | |
| SCHEMBL5270571 | 0.81 | KMT2A (0.59) | HPGDHTTSMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |