Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5270409 | 0.89 | MCL1 (0.52) | MCL1HPGDTSHRACLYMAPK1 | |
| SCHEMBL5271647 | 0.83 | MCL1 (0.46) | MCL1HPGDTSHRACLYMAPK1 | |
| SCHEMBL5270643 | 0.83 | MEN1 (0.55) | MCL1HPGDTSHRACLYMAPK1 | |
| SCHEMBL5265851 | 0.81 | MCL1 (0.48) | MCL1HPGDTSHRACLYMAPK1 | |
| SCHEMBL5271640 | 0.80 | KCNA5 (0.51) | MCL1HPGDTSHRACLYMAPK1 | |
| SCHEMBL5268776 | 0.79 | CCKAR (0.52) | MCL1HPGDTSHRACLYMEN1 | |
| SCHEMBL5269115 | 0.77 | HPGD (0.48) | HPGDMAPK1MEN1KMT2APOLB | |
| SCHEMBL5265268 | 0.76 | KCNA5 (0.46) | HPGDTSHRMEN1KMT2APOLB | |
| SCHEMBL5270919 | 0.76 | KCNA5 (0.51) | MCL1TSHRMEN1KMT2AHTT | |
| SCHEMBL5271810 | 0.75 | KCNA5 (0.50) | TSHRPOLBMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |