Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | RPA1 | P27694 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272583 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL5266533 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL2910701 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL5269292 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL5267517 | 0.77 | RPA1 (0.46) | SMN1; SMN2MEN1KMT2ARPA1 | |
| SCHEMBL2917351 | 0.77 | SLC16A3 (0.40) | SMN1; SMN2MEN1KMT2AFAAHMGLL | |
| SCHEMBL5268843 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL5522528 | 0.76 | ALOX5 (0.40) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL5266028 | 0.76 | RAB9A (0.39) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A | |
| SCHEMBL5269426 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2ALOX5PTGS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-11-01 | — | — | US | disclosed |
| CN-101001852-A | Pyrazole derivatives | DAIICHI SEIYAKU CO (JP) | 2007-07-18 | — | — | CN | disclosed |
| EP-1785418-A1 | PYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254881-A1 | Pyrazole Derivative | PTGER1, PTGS1, PTGER2 | SMN1; SMN2 3490/4885ALOX5 94/4885PTGS2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.