Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 13/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.50 |
| ▸ | NPC1 | O15118 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16652412 | 0.85 | ALDH1A1 (0.58) | ADORA2AADORA1RAB9AALDH1A1NPC1 | |
| SCHEMBL19439400 | 0.85 | ADORA2A (0.51) | ADORA2AADORA1RAB9AALDH1A1NPC1 | |
| SCHEMBL20659883 | 0.80 | ALDH1A1 (0.48) | ADORA2AADORA1RAB9AALDH1A1NPC1 | |
| SCHEMBL2977154 | 0.77 | ALDH1A1 (0.61) | RAB9AALDH1A1NPC1SMN1; SMN2KDM4E | |
| SCHEMBL14034101 | 0.74 | ALDH1A1 (0.74) | RAB9AALDH1A1NPC1SMN1; SMN2KDM4E | |
| SCHEMBL5120193 | 0.72 | SELE (0.31) | — | |
| SCHEMBL654609 | 0.72 | FGFR1 (0.47) | ADORA2AADORA1RAB9AALDH1A1NPC1 | |
| SCHEMBL16776797 | 0.70 | ADORA2A (0.53) | ADORA2AADORA1RAB9AALDH1A1NPC1 | |
| SCHEMBL23599111 | 0.69 | — | — | |
| SCHEMBL1969445 | 0.69 | KDM4E (0.36) | ALDH1A1KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844052-A1 | THIENO[2,3-D]PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | Pharmacia & Upjohn Company LLC (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006079916-A1 | THIENO [2,3-D] PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-08-03 | — | — | WO | disclosed |