Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | IL2 | P60568 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158739 | 0.82 | KMT2A (0.75) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL12260635 | 0.79 | PKM (0.58) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL9955698 | 0.77 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL3510121 | 0.77 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL29808221 | 0.75 | KMT2A (0.66) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL949044 | 0.74 | KMT2A (0.55) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL3147405 | 0.74 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL4755701 | 0.74 | MEN1 (1.00) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL7980113 | 0.74 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL29722919 | 0.74 | MAP4K4 (1.00) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | disclosed |
| EP-1846388-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2007-10-24 | — | — | EP | disclosed |
| US-20060199845-A1 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2006-09-07 | — | — | US | disclosed |
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199845-A1 | Thiophene compounds for inflammation and immune-related uses | CXCR2, TPMT, CXCR1 | MEN1 4484/4885KMT2A 3925/4885MAP4K4 4151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.