Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 10/20 | 0.96 |
| ▸ | MAPT | P10636 | 6/20 | 0.96 |
| ▸ | MAOB | P27338 | 6/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | BCHE | P06276 | 2/20 | 0.96 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.96 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.96 |
| ▸ | ACHE | P22303 | 1/20 | 0.96 |
| ▸ | RECQL | P46063 | 1/20 | 0.96 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.96 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | HSPD1 | P10809 | 3/20 | 0.75 |
| ▸ | HSPE1 | P61604 | 3/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.75 |
| ▸ | RELA | Q04206 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chalcone SCHEMBL2404758 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27580 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL28306720 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27581 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL29922932 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL29396001 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL454583 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL7861207 | 0.96 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL2427445 | 0.96 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL7653806 | 0.96 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316822-A | Chalcone compound HDPC-12 as well as medicine composition, preparation method and application thereof | 浙江海洋学院 | 2017-01-11 | — | — | CN | disclosed |
| EP-2598512-A1 | VINYLOGOUS CHALCONE DERIVATIVES AND THEIR MEDICAL USE | Medizinische Universität Wien (AT) | 2013-06-05 | — | — | EP | disclosed |
| US-20130123367-A1 | VINYLOGOUS CHALCONE DERIVATIVES AND THEIR MEDICAL USE | MEDIZINISCHE UNIVERSITAT WIEN (AT) | 2013-05-16 | — | — | US | disclosed |
| US-8163567-B2 | Methods and compositions comprising capture agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-04-24 | — | — | US | disclosed |
| WO-2012013725-A1 | VINYLOGOUS CHALCONE DERIVATIVES AND THEIR MEDICAL USE | MEDIZINISCHE UNIVERSITÄT WIEN (AT) | 2012-02-02 | — | — | WO | disclosed |
| US-20100256006-A1 | Methods and Compositions Comprising Capture Agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-10-07 | — | — | US | disclosed |
| US-7736909-B2 | Methods and compositions comprising capture agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-06-15 | — | — | US | disclosed |
| US-20040161798-A1 | Methods and compositions comprising capture agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123367-A1 | VINYLOGOUS CHALCONE DERIVATIVES AND THEIR MEDICAL USE | MALT1, VHL, ETV6 | CYP1B1 149/4885MAPT 3074/4885MAOB 3578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.