Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Chalcone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.96 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.75 |
| ▸ | HDAC3 known ✓ | O15379 | 2/20 | 0.70 |
| ▸ | HDAC4 known ✓ | P56524 | 2/20 | 0.70 |
| ▸ | HDAC1 known ✓ | Q13547 | 2/20 | 0.70 |
| ▸ | HDAC7 known ✓ | Q8WUI4 | 2/20 | 0.70 |
| ▸ | HDAC2 known ✓ | Q92769 | 2/20 | 0.70 |
| ▸ | HDAC10 known ✓ | Q969S8 | 2/20 | 0.70 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 2/20 | 0.70 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 2/20 | 0.70 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 2/20 | 0.70 |
| ▸ | HDAC9 known ✓ | Q9UKV0 | 2/20 | 0.70 |
| ▸ | HDAC5 known ✓ | Q9UQL6 | 2/20 | 0.70 |
| ▸ | CYP1B1 | Q16678 | 10/20 | 0.96 |
| ▸ | MAPT | P10636 | 6/20 | 0.96 |
| ▸ | MAOB | P27338 | 6/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | BCHE | P06276 | 2/20 | 0.96 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.96 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chalcone SCHEMBL27827950 | 1.00 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27391389 | 1.00 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL2404758 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27580 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL28306720 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27581 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL29922932 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL454583 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL29396001 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL2427445 | 0.96 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-52078857-A | — | — | None | — | — | JP | disclosed |
| JP-52078857-A | — | — | None | — | — | JP | disclosed |
| JP-52078858-A | — | — | None | — | — | JP | disclosed |
| JP-52078858-A | — | — | None | — | — | JP | disclosed |
| JP-52078856-A | — | — | None | — | — | JP | disclosed |
| JP-52078856-A | — | — | None | — | — | JP | disclosed |
| JP-2001122739-A | HAIR TONIC | SHISEIDO CO LTD | 2001-05-08 | — | — | JP | disclosed |
| US-4085135-A | ANTIULCER | TAISHO PHARMACEUTICAL CO., LTD. (JA) | 1978-04-18 | — | — | US | disclosed |
| JP-S5278856-A | PREPARATION OF CHALCONE ETHERS | TAISHO PHARMACEUT CO LTD | 1977-07-02 | — | — | JP | disclosed |
| JP-S5278858-A | PREPARATION OF CHALCONE ETHERS | TAISHO PHARMACEUT CO LTD | 1977-07-02 | — | — | JP | disclosed |
| JP-S5278856-A | PREPARATION OF CHALCONE ETHERS | TAISHO PHARMACEUT CO LTD | 1977-07-02 | — | — | JP | disclosed |
| JP-S5278858-A | PREPARATION OF CHALCONE ETHERS | TAISHO PHARMACEUT CO LTD | 1977-07-02 | — | — | JP | disclosed |
| US-3928421-A | Anti-gastric ulcer chalcone ethers | TAISHO PHARMACEUTICAL CO LTD | 1975-12-23 | — | — | US | disclosed |
| US-3928421-A | Anti-gastric ulcer chalcone ethers | TAISHO PHARMACEUTICAL CO LTD | 1975-12-23 | — | — | US | disclosed |
| JP-S05278857-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-S05278857-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-S05278858-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-S05278858-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-S05278856-A | — | — | 0001-01-01 | — | — | JP | disclosed |
| JP-S05278856-A | — | — | 0001-01-01 | — | — | JP | disclosed |