SCHEMBL5272449

SCHEMBL5272449

COc1ccc2c(CC(N)C(=O)O)cc(=O)oc2c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 7/20 0.67
▸ LCK P06239 1/20 0.67
▸ ALDH1A1 P00352 6/20 0.62
▸ HPGD P15428 4/20 0.62
▸ CYP2D6 P10635 2/20 0.60
▸ CA12 O43570 3/20 0.57
▸ CA1 P00915 3/20 0.57
▸ CA2 P00918 3/20 0.57
▸ CA9 Q16790 3/20 0.57
▸ CA3 P07451 1/20 0.57
▸ CA4 P22748 1/20 0.57
▸ CA5A P35218 1/20 0.57
▸ CA7 P43166 1/20 0.57
▸ CA14 Q9ULX7 1/20 0.57
▸ CA5B Q9Y2D0 1/20 0.57
▸ HSD17B10 Q99714 2/20 0.56
▸ LMNA P02545 1/20 0.56
▸ NPSR1 Q6W5P4 1/20 0.56
▸ CYP19A1 P11511 1/20 0.55
▸ MEN1 O00255 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10061011 1.00 KDM4E (0.67) KDM4ELCKALDH1A1HPGDCYP2D6
SCHEMBL14473551 1.00 KDM4E (0.67) KDM4ELCKALDH1A1HPGDCYP2D6
SCHEMBL31537502 1.00 KDM4E (0.67) KDM4ELCKALDH1A1HPGDCYP2D6
SCHEMBL5622778 0.94 KDM4E (0.61) KDM4ELCKALDH1A1HPGDCYP2D6
SCHEMBL5622781 0.94 KDM4E (0.61) KDM4ELCKALDH1A1HPGDCYP2D6
Trifluoroacetic Acid SCHEMBL5622459 0.93 KDM4E (0.60) KDM4ELCKALDH1A1HPGDCYP2D6
Trifluoroacetic Acid SCHEMBL6028156 0.93 KDM4E (0.60) KDM4ELCKALDH1A1HPGDCYP2D6
Trifluoroacetic Acid SCHEMBL5622457 0.93 KDM4E (0.60) KDM4ELCKALDH1A1HPGDCYP2D6
SCHEMBL17874880 0.90 KDM4E (0.64) KDM4ELCKALDH1A1HPGDCYP2D6
SCHEMBL16728147 0.90 KDM4E (0.64) KDM4ELCKALDH1A1HPGDCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY FELDAN BIO INC. (CA) 2024-06-20 — — US claimed
CN-117750978-A Synthetic peptide shuttle bioconjugates for intracellular cargo delivery 费尔丹生物公司 2024-03-22 — — CN claimed
US-20230399661-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGTH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS FELDAN BIO INC. (CA) 2023-12-14 — — US claimed
CN-116615205-A Peptide-based transduction of non-anionic polynucleotide analogs for modulation of gene expression 费尔丹生物公司 2023-08-18 — — CN claimed
CN-116615227-A Minimum length shuttle peptide suitable for transduction of Cas9-RNP and other nucleoprotein loads and variants thereof 费尔丹生物公司 2023-08-18 — — CN claimed
CN-114008210-A Peptide-based non-protein cargo delivery 费尔丹生物公司 2022-02-01 — — CN claimed
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY FELDAN BIO INC. (CA) 2024-06-20 — — US disclosed
CN-117750978-A Synthetic peptide shuttle bioconjugates for intracellular cargo delivery 费尔丹生物公司 2024-03-22 — — CN disclosed
US-20230399661-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGTH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS FELDAN BIO INC. (CA) 2023-12-14 — — US disclosed
US-20230383291-A1 PEPTIDE-BASED TRANSDUCTION OF NON-ANIONIC POLYNUCLEOTIDE ANALOGS FOR GENE EXPRESSION MODULATION FELDAN BIO INC. (CA) 2023-11-30 — — US disclosed
EP-4201951-B1 METHOD FOR PEPTIDE SYNTHESIS BACHEM HOLDING AG (CH) 2023-11-22 — — EP disclosed
CN-116615205-A Peptide-based transduction of non-anionic polynucleotide analogs for modulation of gene expression 费尔丹生物公司 2023-08-18 — — CN disclosed
CN-116615227-A Minimum length shuttle peptide suitable for transduction of Cas9-RNP and other nucleoprotein loads and variants thereof 费尔丹生物公司 2023-08-18 — — CN disclosed
US-20050287622-A1 High throughput assays for the proteolytic activities of clostridial neurotoxins ARMY, UNITED STATES 2005-12-29 — — US disclosed
WO-2005075448-A2 A METHOD FOR MANUFACTURING OPTICALLY PURE COUMARYL AMINO ACIDS SALTS AND THE COUMARYL AMINO ACID SALTS THUS OBTAINED INSTITUT NATIONAL DE LA RECHERCHE MEDICALE (INSERM) (FR) 2005-08-18 — — WO disclosed
US-20040146963-A1 High throughput assays for the proteotytic activities of clostridial neurotoxins UNITED STATES ARMY 2004-07-29 — — US disclosed
US-6762280-B2 CLOSTRIDIAL NEUROTOXIN SUBSTRATE FOR USE AS DIAGNOSTIC TOOL IN GENETIC ENGINEERING THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY 2004-07-13 — — US disclosed
EP-1419390-A2 HIGH-THROUGHPUT ASSAYS FOR THE PROTEOLYTIC ACTIVITIES OF CLOSTRIDIAL NEUROTOXINS U.S. Medical Research Institute of Infectious Diseases (US) 2004-05-19 — — EP disclosed
US-20030077685-A1 High throughput assays for the proteotytic activities of clostridial neurotoxins UNITED STATES ARMY 2003-04-24 — — US disclosed
WO-2002025284-A2 HIGH-THROUGHPUT ASSAYS FOR THE PROTEOLYTIC ACTIVITIES OF CLOSTRIDIAL NEUROTOXINS U.S. MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES (US) 2002-03-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY SCAMP2, SLC7A1, NUMA1 KDM4E 4852/4885LCK 3166/4885ALDH1A1 4747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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