Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNPH1 | O43598 | 1/20 | 0.62 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.61 |
| ▸ | ATG7 | O95352 | 1/20 | 0.61 |
| ▸ | UBA7 | P41226 | 1/20 | 0.61 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.61 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.61 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | NPY1R | P25929 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NPY2R | P49146 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991739 | 1.00 | DNPH1 (0.62) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL1794995 | 1.00 | DNPH1 (0.62) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL12566838 | 0.91 | DNPH1 (0.62) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL32662019 | 0.91 | DNPH1 (0.75) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL1794568 | 0.88 | SLC29A1 (0.64) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL1796363 | 0.87 | UBA6 (0.59) | UBA6ATG7UBA7NAE1UBA3 | |
| SCHEMBL12566425 | 0.85 | DNPH1 (0.62) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL32662283 | 0.84 | ADORA1 (0.66) | UBA6ATG7UBA7NAE1UBA3 | |
| SCHEMBL23355143 | 0.83 | DNPH1 (0.59) | DNPH1UBA6ATG7UBA7NAE1 | |
| SCHEMBL30442836 | 0.83 | DNPH1 (0.59) | DNPH1UBA6ATG7UBA7NAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848718-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006084281-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |