Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8729276 | 0.82 | TSHR (0.47) | TSHRALDH1A1CYP19A1CYP1A2CYP2D6 | |
| SCHEMBL8089113 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPK1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10650965 | 0.79 | PTPN1 (0.63) | TSHRALDH1A1MAPK1CYP19A1PTPN1 | |
| SCHEMBL11778113 | 0.78 | ALDH1A1 (0.47) | TSHRALDH1A1MAPK1LMNARORC | |
| SCHEMBL11801017 | 0.78 | TSHR (0.54) | TSHRALDH1A1CYP19A1PTPN1CYP1A2 | |
| SCHEMBL27713784 | 0.78 | TSHR (0.54) | TSHRALDH1A1CYP19A1PTPN1CYP1A2 | |
| SCHEMBL10918542 | 0.78 | TSHR (0.71) | TSHRALDH1A1CYP19A1CYP1A2CYP2D6 | |
| SCHEMBL29864638 | 0.76 | TSHR (0.65) | TSHRALDH1A1CYP19A1CYP1A2CYP2D6 | |
| SCHEMBL5250015 | 0.76 | TSHR (0.65) | TSHRALDH1A1CYP19A1CYP1A2CYP2D6 | |
| SCHEMBL5270747 | 0.74 | LTA4H (0.48) | TSHRALDH1A1MAPK1CYP19A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287716-A1 | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors | MERCK SHARP & DOHME CORP. | 2007-12-13 | — | — | US | disclosed |
| CN-101048384-A | Pyrimidine and quinoline potentiators of metabotropic glutamate receptors | MERCK & CO INC (US) | 2007-10-03 | — | — | CN | disclosed |
| EP-1809608-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006049968-A1 | PYRIMIDINE AND QUINOLINE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287716-A1 | Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors | GRM2, GRM1, GRIN2A | TSHR 762/4885ALDH1A1 3466/4885MAPK1 2127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.