Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 8/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527770 | 1.00 | GPR139 (0.51) | GPR139TSHRNPSR1KMT2AHPGD | |
| SCHEMBL526340 | 0.94 | GPR139 (0.55) | GPR139TSHRNPSR1KMT2AHPGD | |
| SCHEMBL526341 | 0.94 | GPR139 (0.55) | GPR139TSHRNPSR1KMT2AHPGD | |
| SCHEMBL526247 | 0.88 | NPSR1 (0.50) | GPR139TSHRNPSR1KMT2AHPGD | |
| SCHEMBL528363 | 0.87 | GPR139 (0.50) | GPR139NPSR1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL528362 | 0.87 | GPR139 (0.50) | GPR139NPSR1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL528733 | 0.85 | TSHR (0.53) | GPR139TSHRKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL528732 | 0.85 | TSHR (0.53) | GPR139TSHRKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL527806 | 0.84 | MMP1 (0.46) | GPR139NPSR1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL527807 | 0.84 | MMP1 (0.46) | GPR139NPSR1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598493-A1 | MATRIX METALLOPROTEINASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2013-06-05 | — | — | EP | claimed |
| WO-2012014114-A1 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | claimed |