Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.73 |
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490968 | 0.85 | HRH3 (1.00) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL5857282 | 0.84 | HRH3 (0.97) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL4994427 | 0.83 | HRH3 (0.94) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL491864 | 0.83 | MAOA (0.59) | HRH3HRH4KCNH2MAOA | |
| SCHEMBL7394783 | 0.83 | HRH3 (0.50) | HRH3KDM4EALDH1A1TDP1HRH4 | |
| SCHEMBL4453239 | 0.80 | HRH3 (0.89) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL5279316 | 0.80 | HRH3 (0.88) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL21814264 | 0.79 | HRH3 (0.86) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL491607 | 0.79 | HRH3 (0.86) | HRH3LTA4HPTGS2PTGS1KDM4E | |
| SCHEMBL5856034 | 0.78 | HRH3 (0.84) | HRH3LTA4HPTGS2PTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | disclosed |