Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL27562283 | 1.00 | PRCP (0.32) | PRCPNOS2NOS3NOS1DPP7 | |
| Threonine SCHEMBL8815158 | 1.00 | PRCP (0.32) | PRCPNOS2NOS3NOS1DPP7 | |
| Threonine SCHEMBL27592182 | 1.00 | PRCP (0.32) | PRCPNOS2NOS3NOS1DPP7 | |
| Threonine SCHEMBL527858 | 1.00 | PRCP (0.32) | PRCPNOS2NOS3NOS1DPP7 | |
| Threonine SCHEMBL28072332 | 0.95 | — | — | |
| Threonine SCHEMBL6520771 | 0.93 | — | — | |
| Asparagine SCHEMBL28801819 | 0.93 | CD274 (0.33) | NOS2NOS3NOS1GRIA1GRIA2 | |
| Threonine SCHEMBL6520767 | 0.93 | — | — | |
| D-Glutamate SCHEMBL27779763 | 0.92 | GRM8 (0.40) | DPP7KMT2ACYP1A2ALOX15GRIN2D | |
| Glutamine SCHEMBL27823468 | 0.91 | ALOX15 (0.41) | KMT2ACYP1A2ALOX15GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4361279-A2 | PATHOGEN-RESISTANT ANIMALS HAVING MODIFIED CD163 GENES | The Curators of the University of Missouri (US) | 2024-05-01 | — | — | EP | disclosed |
| US-20240122164-A1 | PATHOGEN-RESISTANT ANIMALS HAVING MODIFIED CD163 GENES | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2024-04-18 | — | — | US | disclosed |
| EP-3331355-B1 | PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)-RESISTANT PORCINE AND CELLS HAVING MODIFIED CD163 GENES | UNIV MISSOURI (US) | 2024-04-03 | — | — | EP | disclosed |
| US-20230272397-A1 | METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163 | GENUS PLC (US) | 2023-08-31 | — | — | US | disclosed |
| EP-4145991-A1 | METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163 | Genus Plc (GB) | 2023-03-15 | — | — | EP | disclosed |
| US-11535850-B2 | Methods for improving the health of porcine species by targeted inactivation of CD163 | GENUS PLC (US) | 2022-12-27 | — | — | US | disclosed |
| US-20220135976-A1 | METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163 | GENUS PLC (US) | 2022-05-05 | — | — | US | disclosed |
| US-20220015340-A1 | METHODS FOR PROTECTING PORCINE FETUSES FROM INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2022-01-20 | — | — | US | disclosed |
| US-11208659-B2 | Pig with a genetically modified CD163 gene resistant to PRRSv | GENUS PLC (US) | 2021-12-28 | — | — | US | disclosed |
| WO-2021224599-A1 | METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163 | GENUS PLC (US) | 2021-11-11 | — | — | WO | disclosed |
| US-8877896-B2 | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders | TUFTS UNIVERSITY (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130149373-A1 | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders | TUFTS UNIVERSITY (US) | 2013-06-13 | — | — | US | disclosed |
| WO-2012016162-A2 | COMPOSITIONS, METHODS AND KITS FOR MODELING, DIAGNOSING, AND TREATING COMPLEMENT DISORDERS | TUFTS UNIVERSITY (US) | 2012-02-02 | — | — | WO | disclosed |
| US-7485712-B2 | Protein kinase (NPK-110) | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2009-02-03 | — | — | US | disclosed |
| EP-0791067-B1 | PROTEIN KINASE NPK-110 | MAX PLANCK GESELLSCHAFT (DE) | 2008-12-17 | — | — | EP | disclosed |
| US-20040038361-A1 | Novel protein kinase (NPK-110) | MANDELKOW ECKHARD (DE) | 2004-02-26 | — | — | US | disclosed |
| US-6579691-B1 | DNA sequence encoding a neuronal protein kinase (NPK) which phosphorylates tau proteins as well as other microtubule associated proteins (MAPs) in positions crucial for the binding to microtubules, alzheimers disease, antitumor | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN, E.V. (DE) | 2003-06-17 | — | — | US | disclosed |
| CN-1327388-A | Modified antibodies of induced anti-idiotype reaction enhancement | EURO CELTIQUE SA (BM) | 2001-12-19 | — | — | CN | disclosed |
| EP-0791067-A2 | PROTEIN KINASE NPK-110 | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (DE) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996013592-A2 | PROTEIN KINASE NPK-110 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1996-05-09 | — | — | WO | disclosed |