Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL6520771 | 1.00 | — | — | |
| Threonine SCHEMBL28072332 | 0.98 | — | — | |
| D-Glutamate SCHEMBL27546761 | 0.94 | GRM8 (0.36) | — | |
| Threonine SCHEMBL8815158 | 0.93 | PRCP (0.32) | — | |
| Threonine SCHEMBL527858 | 0.93 | PRCP (0.32) | — | |
| Threonine SCHEMBL527856 | 0.93 | PRCP (0.32) | — | |
| Threonine SCHEMBL27592182 | 0.93 | PRCP (0.32) | — | |
| Threonine SCHEMBL27562283 | 0.93 | PRCP (0.32) | — | |
| D-Glutamate SCHEMBL27454805 | 0.91 | GRM8 (0.34) | — | |
| Threonine SCHEMBL11969543 | 0.91 | NOS2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050164969-A1 | Method of extending life span | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-07-28 | — | — | US | disclosed |