Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528301 | 0.87 | MAPT (0.48) | MAPTCYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL528817 | 0.85 | ALDH1A1 (0.48) | MAPTCYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL529730 | 0.84 | MAPT (0.58) | MAPTCYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL528658 | 0.84 | ALDH1A1 (0.53) | MAPTCYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL528754 | 0.83 | MAPT (0.56) | MAPTCYP2C19NPSR1RAB9AKDM4E | |
| SCHEMBL528344 | 0.82 | MAPT (0.56) | MAPTNPSR1KDM4EALDH1A1LMNA | |
| SCHEMBL528550 | 0.81 | ALDH1A1 (0.55) | MAPTGAANPSR1RAB9AKDM4E | |
| SCHEMBL528386 | 0.81 | MAPT (0.53) | MAPTGAANPSR1RAB9AKDM4E | |
| SCHEMBL528646 | 0.80 | ALDH1A1 (0.59) | MAPTGAANPSR1KDM4EALDH1A1 | |
| SCHEMBL528307 | 0.80 | KMT2A (0.63) | MAPTGAANPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |