Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5276784 | 0.90 | EPHX2 (0.37) | EPHX2SLC2A1ACKR3HTR7 | |
| SCHEMBL5276039 | 0.80 | PDCD1 (0.33) | HTR7 | |
| SCHEMBL6027281 | 0.79 | PDCD1 (0.37) | ACKR3 | |
| SCHEMBL2639950 | 0.76 | CHRM2 (0.37) | POLBKDM4EALDH1A1 | |
| SCHEMBL5281205 | 0.76 | ACKR3 (0.32) | ACKR3 | |
| SCHEMBL5272613 | 0.75 | PDCD1 (0.38) | POLBALDH1A1 | |
| SCHEMBL5722183 | 0.73 | HPGD (0.40) | ALDH1A1 | |
| SCHEMBL4694436 | 0.73 | NPC1 (0.38) | ALDH1A1 | |
| SCHEMBL4695640 | 0.72 | PDCD1 (0.34) | ACKR3 | |
| SCHEMBL2639688 | 0.72 | POLB (0.44) | EPHX2POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856112-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006099032-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-09-21 | — | — | WO | claimed |