Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5810881 | 0.88 | SMN1; SMN2 (0.37) | HPGDALDH1A1LMNATP53MAPT | |
| SCHEMBL4695511 | 0.88 | PDCD1 (0.34) | CD274SMN1; SMN2HDAC1 | |
| SCHEMBL5224728 | 0.87 | HPGD (0.39) | HPGDALDH1A1LMNAMCHR1SPHK2 | |
| SCHEMBL4694436 | 0.87 | NPC1 (0.38) | HPGDALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5272930 | 0.85 | SPHK2 (0.34) | HPGDALDH1A1LMNATP53MAPT | |
| SCHEMBL6027738 | 0.85 | ESRRG (0.40) | MAPTMCHR1CD274SMN1; SMN2NAMPT | |
| SCHEMBL5273742 | 0.83 | NAMPT (0.35) | HPGDLMNATP53MAPTSPHK2 | |
| SCHEMBL4691523 | 0.82 | TPSAB1 (0.36) | ALDH1A1MAPTMCHR1SMN1; SMN2NAMPT | |
| SCHEMBL5276249 | 0.81 | SMYD2 (0.33) | HPGDALDH1A1LMNASPHK2CD274 | |
| SCHEMBL5278178 | 0.80 | ALDH1A1 (0.35) | HPGDALDH1A1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685118-A2 | COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | Theravance, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051946-A2 | COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | THERAVANCE, INC. (US) | 2005-06-09 | — | — | WO | disclosed |